刘晓红
生物工程专业：硕士生导师
生物学专业：博士生导师/硕士生导师
生物与医药专业（生物工程领域）：硕士生导师
刘晓红，女，博士，williamhill威廉希尔官网副教授，主要从事海洋鱼类疫苗开发及免疫应答机制研究，专注于鱼类疫苗及佐剂设计、临床应用研究与生产应用开发工作。主持国家自然科学基金面上项目、青年项目、国家重点研究计划课题、上海市自然基金面上项目、重点科研基地创新基金中央高校基本科研业务费重点科研基地创新基金等。主持申报并获批农业农村部渔用疫苗临床试验批件2项，负责大菱鲆鳗弧菌基因工程活疫苗国家一类新兽药注册证书申报并获批。累计发表SCI论文20余篇。
研究方向
1. 水生动物免疫机制与疫苗免疫学研究
2. 疫苗递送系统构建与新型免疫佐剂创制
代表性论文
[1] Fei Sun, Yingbo Wu, Yuanxing Zhang, Qin Liu, Qiyao Wang, Xiaohong Liu*. An aluminium adjuvant compound with ginseng stem leaf saponins enhances the potency of inactivated Pseudomonas plecoglossicida vaccine in large yellow croaker (Larimichthys crocea). Fish and Shellfish Immunology, 2024, 144: 109243.
[2] Jie Zhou, Ruofan Yu, Yue Ma, Qiyao Wang, Qin Liu, Yuanxing Zhang, Xiaohong Liu*. A bacterial ghost vaccine against Aeromonas salmonicida infection in turbot (Scophthalmus maximus). Fish and Shellfish Immunology，2024,151: 109711.
[3] Di Wu, Shuai Shao, Qin Liu, Qiyao Wang, Yuanxing Zhang, Xiaohong Liu*. Protection of a CpG-adjuvanted DNA vaccine against infectious hematopoietic necrosis virus (IHNV) nature infection in rainbow trout (Oncorhynchus mykiss). Aquaculture, 2023, 572: 739555.
[4] Fei Sun, Jie Zhou, Yuanxing Zhang, Qin Liu, Qiyao Wan, Xiaohong Liu*. A compound ginseng stem leaf saponins and aluminium adjuvant enhances the potency of inactivated Aeromonas salmonicida vaccine in turbot. Fish and Shellfish Immunology, 2022, 128: 60-66.
[5] Wenwen Wang, Wei Wang, Wenjun Xu, Qin Liu, Yuanxing Zhang, Xiaohong Liu*. Polyactin A and CpG enhance inactivated Pseudomonas plecoglossicida vaccine potency in large yellow croaker (Larimichthys crocea). Fish and Shellfish Immunology, 2021, 120: 133-138.
[6] Peng Jin, Fei Sun, Qin Liu, Qiyao Wang, Yuanxing Zhang, Xiao Hong Liu*. An oral vaccine based on chitosan/aluminum adjuvant induces both local and systemic immune responses in turbot (Scophthalmus maximus). Vaccine, 2021, 39: 7477-7484.
[7] Xiang Sun, Peng Jin, Qin Liu, Qiyao Wang, Yuanxing Zhang, Xiaohong Liu*. A CpG-riched plasmid as vaccine adjuvant reduce antigen dose of an inactivated Vibrio anguillarum vaccine in turbot (Scophthalmus maximus L.). Fish and Shellfish Immunology, 2020, 98: 312–317.
[8] Yue Ma, Yabo Liu, Yanyan Wu, Jia Lei*, Xiaohong Liu*, Qiyao Wang, Yuanxing Zhang. An attenuated Vibrio harveyi surface display of envelope protein VP28 to be protective against WSSV and vibriosis as an immunoactivator for Litopenaeus vannamei. Fish and Shellfish Immunology, 2019, 95: 195-202.
[9] Tianjian Hu, Ran Chen, Lingzhi Zhang, Zhuang Wang, Dahai Yang, Yuanxing Zhang, Xiaohong Liu*, Qin Liu*. Balanced role of T3SS and T6SS in contribution to the full virulence of Edwardsiella piscicida. Fish and Shellfish Immunology, 2019, 93: 871-878.
[10] Dahai Yang#, Xiaohong Liu#, Wenting Xu, Zhaoyan Gu, Cuiting Yang, Lingzhi Zhang, Jingchao Tan, Xin Zheng, Zhuang Wang, Shu Quan, Yuanxing Zhang, Qin Liu. The Edwardsiella piscicida thioredoxin-like protein inhibits ASK1-MAPKs signaling cascades to promote pathogenesis during infection. PloS Pathogens, 2019, 15: e1007917.
[11] Pengcheng Bao, Xiang Sun, Qin Liu, Yuanxing Zhang, Xiaohong Liu*. Synergistic effect of a combined live Vibrio anguillarum and Edwardsiella piscicida vaccine in turbot. Fish and Shellfish Immunology, 2019, 88: 84-90.
[12] Tianjian Hu, Lingzhi Zhang, Wei Wang, Dahai Yang, Jingfan Xiao, Yuanxing Zhang, Xiaohong Liu*, Qin Liu*. Edwardsiella piscicida enters nonphagocytic cells via a macropinocytosis-involved hybrid mechanism. Journal of Bacteriology, 2019, 201: e00548.
[13] Wenting Xu, Chenglong Jiao, Pengcheng Bao, Qin Liu, Pengbo Wang, Ruilin Zhang, Xiaohong Liu*, Yuanxing Zhang. Efficacy of Montanide (TM) ISA 763 A VG as aquatic adjuvant administrated with an inactivated Vibrio harveyi vaccine in turbot (Scophthalmus maximus L.). Fish and Shellfish Immunology, 2019, 84: 56-61.
[14] Lifan Wei, Yanyan Wu, Haoxian Qiao, Wensheng Xu, Yuanxing Zhang, Xiaohong Liu*, Qiyao Wang*. YebC controls virulence by activating T3SS gene expression in the pathogen Edwardsiella piscicida. FEMS Microbiology Letters, 2018, 365: fny137.
[15] Xiaohong Liu, Chenglong Jiao, Yue Ma*, Qiyao Wang, Yuanxing Zhang. A live attenuated Vibrio anguillarum vaccine induces efficient immunoprotection in Tiger puffer (Takifugu rubripes). Vaccine, 2018, 36: 1460-1466.
[16] Yunpeng Guan, Kaiyu Yin, Mian Zhou, Minjun Yang, Yuanxing Zhang, Xiaohong Liu*, Qiyao Wang*. EsrB negatively regulates expression of the glutamine sythetase GlnA in the fish pathogen Edwardsiella piscicida. FEMS Microbiology Letters, 2018, 365: fny007.
[17] Xiaohong Liu, Jiamin Sun, Haizhen Wu*. Glycolysis-related proteins are broad spectrum vaccine candidates against aquacultural pathogens. Vaccine, 2017, 35: 3813-3816.
[18] Xiaohong Liu, Hua Zhang, Chenglong Jiao, Qin Liu, Yuanxing Zhang, Jingfan Xiao*. Flagellin enhances the immunoprotection of formalin-inactivated Edwardsiella tarda vaccine in turbot. Fish and Shellfish Immunology, 2017, 35: 369-374.
[19] Xiaohong Liu, Jinmei Xu, Hua Zhang, Qin Liu, Jingfan Xiao*, Yuanxing Zhang. Design and evaluation of an Edwardsiella tarda DNA vaccine co-encoding antigenic and adjuvant peptide. Fish and Shellfish Immunology, 2016, 59: 189-195.
[20] Xiaohong Liu, Hua Zhang, Yuan Gao, Yang Zhang, Haizhen Wu*, Yuanxing Zhang. Efficacy of chitosan oligosaccharide as aquatic adjuvant administrated with a formalin-inactivated Vibrio anguillarum vaccine. Fish and Shellfish Immunology, 2015, 47: 855-860.
[21] Xiaohong Liu, Haizhen Wu*, Qin Liu, Qiyao Wang, Jingfan Xiao, Xinyue Chang, Yuanxing Zhang. Profiling immune response in zebrafish intestine, skin, spleen and kidney bath-vaccinated with a live attenuated Vibrio anguillarum vaccine. Fish and Shellfish Immunology, 2015, 45: 342-345.
[22] Xiaohong Liu, Haizhen Wu*, Qin Liu, Qiaoyao Wang, Jingfan Xiao, Yuanxing Zhang. Skin-injured zebrafish, Danio rerio, are more susceptible to Vibrio anguillarum infection. Journal of the World Aquaculture Society, 2015, 46: 301-310.
[23] Xiaohong Liu, Xinyue Chang, Haizhen Wu*, Jingfan Xiao, Yuan Gao, Yuanxing Zhang. Role of intestinal inflammation in predisposition of Edwardsiella tarda infection in zebrafish (Danio rerio). Fish and Shellfish Immunology, 2014, 41: 271-278.
[24] Xiaohong Liu, Haizhen Wu*, Xinyue Chang,Yufei Tang, Qin Liu, Yuanxing Zhang. Notable mucosal immune responses induced in the intestine of zebrafish (Danio rerio) bath-vaccinated with a live attenuated Vibrio anguillarum vaccine. Fish and Shellfish Immunology, 2014, 40: 99-108.
承担科研项目
[1] 海水养殖动物细菌疫苗产品创制/国家重点研发计划课题/2023.12-2027.11/主持
[2] AS03/人参茎叶皂苷复方佐剂靶向大菱鲆细胞免疫激活的协同机制研究/国家自然科学基金面上项目/2023.1-2026.12/主持
[3] 针对大菱鲆杀鲑气单胞菌灭活疫苗的复方铝佐剂设计及效应机制研究/上海市自然基金面上项目/2021.7-2024.6/主持
[4] 海洋鱼类浸泡、口服型疫苗的探索性研究/国家重点研发计划子课题/2018.8-2021.12/主持
[5] 可替换Signa因子RpoS在杀鱼爱德华氏菌致病力中的分子调控机制/国家自然科学基金青年项目/2017.1-2019.12/主持
科研著作
[1] Patrick T.K. Woo and Rocco C. Cipriano主编. 王启要, 马悦, 刘晓红主译. 鱼类病毒和细菌：病理学与防控. williamhill威廉希尔官网出版社, 2021, ISBN: 9787562867944.
[2] 马悦, 王启要, 刘晓红, 秦启伟, 曲江波, 李荣, 于凯松. 海水鱼疫苗预防接种管理与实施规程. 标准号: T/HSY 0011-2021.
教学成果荣誉
[1] 第六届上海高校青年教师教学竞赛二等奖
[2] 中国国际大学生创新大赛（2024）上海市金奖（指导教师）
[3] 中国国际大学生创新大赛（2023）全国金奖（指导老师）
[4] 第九届中国国际“互联网+”大学生创新创业大赛上海市金奖（指导老师）
[5] 2023高等院校发明选拔赛金奖（指导老师）
联系方式
邮箱：liuxiaohong@ecust.edu.cn