陈守文 博士
生物工程专业：硕士生导师
【个人简介】
williamhill威廉希尔官网，特聘副研究员。2019年6月毕业于williamhill威廉希尔官网williamhill威廉希尔官网生物化工专业，获工学博士学位，师从刘琴教授。2023年11月博士后出站留校任教至今。迄今已在Science Advances、PLoS Pathogens、Nature Communications等国际权威期刊发表SCI论文10余篇，主持或参与包括国家自然科学基金青年科学基金，中国博士后科学基金，国家重点研发计划“前沿生物技术”重点专项、上海市科技创新面上项目在内的多项国家与省部级基金项目。
【研究方向】
神经炎症介导神经退行性疾病的致病机制及其诊疗方案开发
1.神经炎症促进阿尔茨海默症的致病机制解析；
2.阿尔茨海默症神经炎症血液标志的鉴定及诊断技术；
3.基于阿尔茨海默症神经炎症靶点的基因治疗方案开发。
【教学工作】
研究生专业选修课《现代细胞生物学》，32学时/年，2学分
【科研项目】
1. 国家自然科学基金青年基金项目，32002429，“大菱鲆炎症小体信号通路及其介导的抗菌效应机制”，2021.01-2023.12，24万，主持；
2. 中国博士后科学基金面上资助项目，2020M671033，“杀鱼爱德华氏菌参与调控鱼类非经典炎症小体机制研究”，2020.09-2022.09，8万，主持；
3. 中华人民共和国科学技术部, 国家重点研发计划“前沿生物技术”重点专项, 2022YFC3400100, “基因表达时空精准操控技术研究”, 2022.11-2027.10, 2094.4万, 在研, 承担子课题；
4. 上海市“科技创新行动计划”面上项目，20ZR1415500，“鱼类焦亡信号调控中性粒细胞胞外陷阱功能研究”，2020.02-2023.06，20万元，参与。
【科研论文】
1. Shuxin Li#, Xiaoyang Lu#, Xiuqing Lin, Yuanxing Zhang, Qin Liu, Shouwen Chen*. Cleavage of gasdermin by apoptotic caspases triggers pyroptosis restricting bacterial colonization in Hydra. Dev. Comp. Immunol.，2024, 155:105139.
2. Shouwen Chen, Shuxin Li, Yuxin Gong, Hao Chen, Dahai Yang, Yuanxing Zhang,Qin Liu*. Caspase-mediated LPS sensing and pyroptosis signaling in Hydra. Sci. Adv. 2023, 9(29): eadh4054.
3. Shouwen Chen, Peng Jin，Hao Chen， Di Wu， Shuxin Life，Yuanxing Zhang，Qin Liu， Dahai Yang*. Dual function of a turbot inflammatory caspase in mediating both canonical and non-canonical inflammasome activation. Dev. Comp. Immunol. 2021, 121.
4. Shouwen Chen, Xin Ma, Di Wu, Shijin Wu, Qiyao Wang, Yuanxing Zhang, Qin Liu*. Scophthalmus maximus interleukin-1β limits Edwardsiella piscicida colonization in vivo.Fish Shellfish Immunol., 2019, 95: 277-286.
5. Shouwen Chen, Dahai Yang, Ying Wen, Zhiwei Jiang, Lingzhi Zhang, Jiatiao Jiang, Yaozhen Chen, Tianjian Hu, Qiyao Wang, Yuanxing Zhang, Qin Liu*. Dysregulated hemolysin liberates bacterial outer membrane vesicles for cytosolic lipopolysaccharide sensing. PLoS Pathog. 2018, 14: e1007240.
6. Ying Wen, Shouwen Chen, Zhiwei Jiang, Zhuang Wang, Jinchao Tan, Tianjian Hu, Qiyao Wang, Xiangshan Zhou, Yuanxing Zhang, Qin Liu, Dahai Yang*. Dysregulated haemolysin promotes bacterial outer membrane vesicles induced pyroptotic-like cell death in zebrafish. Cell Microbiol. 2019, 31: e13010.
7. Dahai Yang, Xin Zheng, Shouwen Chen, Zhuang Wang,Wenting Xu, JinchaoTan , Tianjian Hu, Mingyu Hou, Wenhui Wang, Zhaoyan Gu, Qiyao Wang, Ruilin Zhang, Yuanxing Zhang, Qin Liu*. Sensing of cytosolic LPS through caspy2 pyrin domain mediates noncanonical inflammasome activation in zebrafish. Nat Commun. 2018, 9: 3052.
8. Yaozhen Chen, Xiangyang Qin, Qunxing An, Jing Yi, Fan Feng, Dandan Yin, Ning An, Zheng Liu, Lihong Weng, Shouwen Chen, Xingbin Hu*, Wen Yin*. Mesenchymal stromal cells directly promote inflammation by canonical NLRP3 and non-canonical caspase-11 inflammasomes. EBioMedicine. 2018, 32: 31-42.
9. Ying Wen, Yin Wang, Shouwen Chen, Xiangshan Zhou, Yuanxing Zhang, Dahai Yang, Gabriel Núñez, Qin Liu*. Dysregulation of cytosolic c-di-GMP in Edwardsiella piscicida promotes cellular non-canonical ferroptosis. Front Cell Infect Microbiol. 2022, 12: 49.
10. Hao Chen, Xiaomin Wu, Zhaoyan Gu, Shouwen Chen, Xiangshan Zhou, Yuanxing Zhang, Qin Liu, Zhuang Wang*, Dahai Yang*. Zebrafish gasdermin E cleavage-engaged pyroptosis by inflammatory and apoptotic caspases. Dev. Comp. Immunol. 2021,124:104203.
联系方式：
上海市徐汇区梅陇路130号williamhill威廉希尔官网
邮编：200237
办公室：阿华生物工程研究所102室
微信：18017984885
电话：021-64253065
邮箱：swchen@ecust.edu.cn