万民熙
生物工程专业：博士生导师/硕士生导师
生物学专业：博士生导师
食品科学与工程专业：硕士生导师
生物与医药专业（生物工程领域）：博士生导师/硕士生导师
副教授，硕士生导师/博士生导师。中南大学和美国Johns Hopkins University（约翰斯·霍普金斯大学）联合培养博士。
入选上海市东方英才（青年项目）、江苏省“双创人才”、云南省青年千人计划（柔性引才）、williamhill威廉希尔官网青年英才引进与培育计划。
一直从事微藻生物技术、合成生物学和光生物反应器方面的研究工作，专注于生物合成技术的产业化工作，已有多项技术成果实现了产业化。作为项目或课题负责人承担国家重点研发计划课题、863课题、973计划子课题、国家自然科学基金、中央高校基本科研业务费专项基金等多个国家级/省部级项目。在Bioresource Technology、Algal Research、Biotechnology and Bioengineering、Journal of Biotechnology等生物技术领域相关期刊上公开发表论文60余篇；编写专著1本、中英文书稿4章；申请发明专利20余项。
担任九三学社江苏省科技专门委员会委员、中国空间科学学会空间生命专业委员、中国科技核心期刊《现代生物医学进展》常务编委、SCI刊物《Applied Sciences》客座编辑。
教育经历/工作履历
2012/7 - 至今，williamhill威廉希尔官网，williamhill威廉希尔官网，现任副教授、硕士生导师/博士生导师，历任师资博士后、讲师
2007/9 - 2012/6，中南大学，微生物系，博士
2010/1 - 2012/1，Johns Hopkins University，Department of Chemical and Biomolecular Engineering，联合培养博士
2004/9 - 2007/7，中南大学，生物工程系，硕士
1999/9 - 2003/7，中南大学，化学工程系，学士
研究方向
1. 微藻生物技术：高价值生物活性物质（如：类胡萝卜素、蛋白、多糖、脂肪酸）的生产工艺开发与功效研究、分子生物学研究、代谢途径改造、光合细胞工厂优化等。目前多项技术已在功能食品、营养补充剂、化妆品领域实现了产业化。
2. 合成生物学（药物的生物合成）：主要各类微生物细胞为底盘生物，开发强鲁棒性的细胞工厂进行多肽、蛋白质以及萜类等多种活性物质的高效生物合成，并应用机器学习进行表达元件和生物合成过程的深度优化。开发的基于基因表达元件理性设计的重组多肽药物生物合成技术已经成功实现了产业化。光合微生物细胞工厂的高效合成平台完成了户外验证性示范。
3. 光生物反应器：适用于光合微生物及其细胞工厂的光生物反应器的研制与产业化。
承担科研项目
作为负责人承担9个项目/课题：
1. 国家重点研发计划合成生物学领域课题一项（国拨经费362万）
2. 国家高技术研究发展计划863课题“高产虾青素的雨生红球藻‘异养-稀释-光诱导串联’培养新工艺的优化与工业化放大”（国拨经费750万，企业经费800万）
3. 国家重点基础研究发展计划973项目“微藻能源规模化制备的科学基础”-“基于光照方向混合及光衰减特性的光生物反应器设计与放大原理”子课题：“光生物反应器热模验证——雨生红球藻培养工艺优化与放大研究”
4. 国家自然科学基金青年科学基金项目“雨生红球藻厚壁孢子形成对虾青素合成的相关基因转录调控的影响机制”
5. 云南省青年千人计划课题“裸藻工业化生产技术的开发与产业化”，（云南省拨经费70万）
6. williamhill威廉希尔官网2020 年度青年交叉创新提升计划（青椒计划）项目，“异养过程中剪切力对裸藻细胞的伤害机制及其调控”
7. 中国博士后基金，特别资助“雨生红球藻厚壁孢子形成与虾青素合成调控的关联机制”
8. 中国博士后面上项目,一等资助“雨生红球藻异养-光诱导串联培养中细胞形态调控研究”
9. 中央高校基本科研业务费-探索研究基金“雨生红球藻细胞形态转变规律与分子机制及其在细胞培养中的应用”
教学工作
主讲本科生课程《微藻生物技术导论》、《海洋生化工程概论》、《藻类食品及加工技术》，合讲研究生课程《海洋生化工程》。
近年代表性论文（一作或通讯作者）
[1] Kaikai Zhang, Minxi Wan*(通讯作者), Wenmin Bai, Zhengxu Bao, Xingbo Duan, Weiliang Wang, Fei Fan, Yuanguang Li*. A novel heterotrophic cultivation process of Euglena gracilis based on NaCl stress significantly increases the paramylon production. Algal Research, 2024, 78: 103391.
[2] Kaikai Zhang, Minxi Wan*(通讯作者), Wenmin Bai, Maolei He, Weiliang Wang, Fei Fan, Jiacai Guo, Tao Yu, Yuanguang Li*. A novel method for extraction of paramylon from Euglena gracilis for industrial production[J]. Algal Research, 2023, 71: 103058.
[3] Junjie Liao, Zhongnan Fei, Minxi Wan*(通讯作者), Wenmin Bai, Yuanguang Li*. Effects of shear stress and shear protectants on heterotrophic culture of Haematococcus pluvialis, Algal Research, Volume 69, 2023, 102936
[4] Zhongnan Fei, Fei Fan, Junjie Liao, Minxi Wan*(通讯作者), Wenmin Bai, Weiliang Wang, Maolei He, Yuanguang Li*. A novel stepwise dilution strategy to improve astaxanthin production of Haematococcus pluvialis in outdoor horizontal tubular photobioreactors. Algal Research. 2023, 70: 102971
[5] Jiacai Guo, Jie Ling, Kaikai Zhang, Fei Fan, Weiliang Wang, Yuanchan Luo, Minxi Wan*(通讯作者), Yuanguang Li*. A novel ultrasonic crushing method for accurate detection of viable spore counts in Paenibacillus polymyxa-based microbial pesticides is superior to the conventional method of Shaker shaking. Biocontrol Science and Technology, 2023, 3(33): 268-282.
[6] Jiacai Guo, Fei Fan, Weiliang Wang, Minxi Wan*(通讯作者), Yuanguang Li*. Development of PMA-qPCR assay to accurately and reproducible quantify viable bacteria of Paenibacillus polymyxa[J]. Letters in Applied Microbiology, 2023, 76(11):1093.
[7] Tao Yu, Fei Fan, Lei Huang, Weiliang Wang, Minxi Wan*(通讯作者), Yuanguang Li*. Artificial neural networks prediction and optimization based on four light regions for light utilization from Synechocystis sp. PCC 6803, Bioresource Technology, 2023, 130166
[8] Jiacai Guo, Weiliang Wang, Haoyu Zhao, Yuanchan Luo, Minxi Wan*(通讯作者), Yuanguang Li*, A new PMA-qPCR method for rapid and accurate detection of viable bacteria and spores of marine-derived Bacillus velezensis B-9987, Journal of Microbiological Methods, 2022, 199: 106537 2.622
[9] Tao Yu, Jie Ling, Minxi Wan*(通讯作者), Jiangong Zhang, Fei Fan, Weiliang Wang, Yuanguang Li*, Semi-continuous cultivation strategy for improving the growth of Synechocystis sp. PCC 6803 based on the growth model of volume average light intensity, Algal Research, 2022, 67, 102839 （5.276）
[10] Zhongnan Fei, Junjie Liao, Fei Fan, Minxi Wan*(通讯作者), Wenmin Bai, Maolei He, Yuanguang Li*. Improving astaxanthin production by using multivariate statistical analysis to evaluate green cells of Haematococcuspluvialis. Biochemical Engineering Journal, 2022, 183: 108456
[11] Jiangong Zhang, Fei Fan, Tao Yu, Jianpei Chen*, Minxi Wan*(通讯作者), Yuanguang Li. Controlling average number of photons received per biomass to promote the growth of Synechocystis sp. PPC 6803 [J]. Biotechnol Letters, 2022, 44, 767–775
[12] Zhongnan Fei, Fei Fan, Junjie Liao, Minxi Wan*(通讯作者), Wenmin Bai, Weiliang Wang, Maolei He, Yuanguang Li*. Improving astaxanthin production of Haematococcus pluvialis on the outdoor large scale cultivation by optimizing the disinfection strategy of photobioreactor. Algal Research, 2022, 64: 102708
[13] Fei Fan, Zhongnan Fei, Minxi Wan*(通讯作者), Jianke Huang, Weiliang Wang, Wenmin Bai, Maolei He, Yuanguang Li*. The optimization of centrifugal pump driving horizontal tubular photobioreactor for enhancing astaxanthin production using heterotrophic Haematococcus pluvialis. Journal of Biotechnology, 2021, 341: 168–174
[14] Minxi Wan, Haoyu Zhao, Jiacai Guo, Lulu Yan, Daojing Zhang, Wenmin Bai, Yuanguang Li*, Comparison of C-phycocyanin from extremophilic Galdieria sulphuraria and Spirulina platensis on stability and antioxidant capacity, Algal Research, 2021, 58: 102391
[15] Lei Fang, Jingkui Zhang, Zhongnan Fei, Minxi Wan*(通讯作者), Astaxanthin accumulation difference between non-motile cells and akinetes of Haematococcus pluvialis was affected by pyruvate metabolism, Bioresources and Bioprocessing, 2020, 7, 5、
[16] Zhen Zhang, Yingying Tan, Weiliang Wang, Wenmin Bai, Jianhua Fan, Jianke Huang, Minxi Wan*(通讯作者), Yuanguang Li*, Efficient heterotrophic cultivation of Chlamydomonas reinhardtii. Journal of applied phycology, 2019,31(3): 1545–1554
[17] Haohua Wang, Zhen Zhang, Minxi Wan*(通讯作者),, Ruixuan Wang, Jianke Huang, Kaikai Zhang, Jiacai Guo, Wenmin Bai, Yuanguang Li*, Comparative study on light attenuation models of Galdieria sulphuraria for efficient production of phycocyanin, Journal of applied phycology, 2019, 32, 165–174
[18] Minxi Wan, Zhen Zhang*, Ruixuan Wang, Wenmin Bai, Jianke Huang, Weiliang Wang, Guomin Shen, Anquan Yu, Yuanguang Li*, High-yield cultivation of Botryococcus braunii for biomass and hydrocarbons, Biomass and Bioenergy, 2019, 131, 105399
[19] Lei Fang, Jingkui Zhang, Zhongnan Fei, Minxi Wan*(通讯作者), Chlorophyll as key indicator to evaluate astaxanthin accumulation ability of Haematococcus pluvialis, Bioresources and Bioprocessing, 2019, 6, 52
[20] Weiliang Wang, Tingting Wei, Jianhua Fan, Jun Yi, Yuanguang Li*, Minxi Wan*(通讯作者), Jun Wang, Wenmin Bai. Repeated mutagenic effects of 60Co-γ irradiation coupled with high-throughput screening improves lipid accumulation in mutant strains of the microalgae Chlorella pyrenoidosa as a feedstock for bioenergy. Algal Research, 2018, 33:71-77
[21] Bin Sheng, Fei Fan, Jianke Huang, Wenmin Bai, Jun Wang, Sulan Li, WeiLi, Minxi Wan*（通讯作者）, Yuanguang Li*. Investigation on models for light distribution of Haematococcus pluvialis during astaxanthin accumulation stage with an application case. Algal Research, 2018, 33:182-189
[22] Minxi Wan, Zhenyang Wang, Zhen Zhang, Jun Wang, Shulan Li, Anquan Yu, Yuanguang Li*. A novel paradigm for the high-efficient production of phycocyanin from Galdieria sulphuraria. , Bioresource Technology, 2016, 218: 272-278
[23] Dongda Zhang*#, Minxi Wan#（并列一作）, Ehecatl A. del Rio-Chanona, Jianke Huang, Weiliang Wang, Yuanguang Li, Vassilios S. Vassiliadis*. Dynamic Modelling of Haematococcus pluvialis Photoinduction for Astaxanthin Production in both Attached and Suspended Photobioreactors, Algal Research, 2016, 13: 69-78
[24] Minxi Wan#, Zhen Zhang#, Jun Wang, Jianke Huang, Jianhua Fan, Anquan Yu, Weiliang Wang, Yuanguang Li*. Sequential Heterotrophy–Dilution–Photoinduction Cultivation of Haematococcus pluvialis for efficient production of astaxanthin, Bioresource Technology, 2015, 198: 557-563
[25] Minxi Wan, Jingkui Zhang, Dongmei Hou, Jianhua Fan, Yuanguang Li *, Jianke Huang, Jun Wang, The effect of temperature on cell growth and astaxanthin accumulation of Haematococcus pluvialis during a light-dark cyclic cultivation. Bioresource Technology, 2014, 167(8):1958-1964
[26] Minxi Wan, Xuejie Jin, Jinlan Xia *, Julian N. Rosenberg, Geng Yu, Zhenyuan Nie, George A. Oyler, Michael J. Betenbaugh *. The effect of iron on growth, lipid accumulation, and gene expression profile of the freshwater microalga Chlorella sorokiniana. Applied Microbiology and Biotechnology, 2014, 98(22):9473-9481
[27] Minxi Wan#, Dongmei Hou#, Yuanguang Li*, Jianhua Fan, Jianke Huang, Songtao Liang, Weiliang Wang, Ronghua Pan, Jun Wang, Shulan Li. The effective photoinduction of Haematococcus pluvialis for accumulating astaxanthin with attached cultivation. Bioresource Technology, 2014, 163(4), 26-32
联系方式：上海市梅陇路130号实验18楼1101室；电话：18621924712，021-64252104
E-mail：wanminxi@ecust.edu.cn